SoluPath Flex™– The Customizable, Fixed-Price Solution toRapidly Improve Solubility
Low solubility is a common but complex hurdle on thepath to Phase I trials and commercialization. Through SoluPath Flex™,your project will be initiated and completed by a dedicated early developmentteam of experts. Our early development labs afford us the agility of a start-upwith the deep resources and expertise of a global pharmaceutical developmentleader.
AccelerateDevelopment with a Customized Solubility Enhancement Solution
Simplicity and Clarity – Build the Best Solution Knowing Exact Costsand Timelines:The simplicity begins with a menu of services, where fixed costs and timing arespelled out in black and white.
Customizable – More Choices and More Efficiency: Select from a full array oftechnologies and services to tailor a unique solution that’s as unique as yourchallenges.
Expert Advice – A Solution Built on Scientific Expertise: At the first meeting you’llwork directly with a solubility expert from Patheon to design a solution tomeet your unique requirements.
Fast – Get responsive service and rapid results. In just one meeting you’llknow the approach, cost, timing and API requirements followed quickly byaquote.
Only with SoluPath Flex™ can you plan,quote and launch a solubility enhancement solution custom tailored for yourmolecule, timeline and budget.
SoluPath Flex™ Technologies
Drug Substance Characterization: Evaluate and understand the physical behaviorand characteristics of your API. Leverage physical data to drive productdevelopment needs.
Solid Dispersions: Super saturated formulations that improve solubility, enhancingkinetic stability in a thermodynamically unfavorable state. Often this methodachieves bioavailability targets where other options fail.
Microparticles: Micronization increases the surface area of particles to enhance thesurface area for dissolution. This is a quick, low-cost, low-risk method ofincreasing bioavailability for many low solubility APIs.
Solubility Enhancement: Deploys an armory of solvents, co-solvents,surfactants, complexing agents, and crystallization inhibitors to improveabsorption and enable larger dose volumes.
Lipid-Based Formulations: Improves absorption by using lipids, solventsand/or surfactants that solubilize, disperse and transport drugs across the gutwall.
Prototypes: Evaluate stability and performance, scale-up your product.Leverage screening information to produce prototypes for stability testing and TOestablish manufacturing processes.
Stability: Test chemical and physical stability of your lead formulation. Ensurethe chosen technique is suitable for in vivo studies.
Manufacturing: Produce the lead drug product for PK or animal tox studies at the samefacility. Test your enhanced formulation versus non-enhanced formulations.
SoluPath Flex™ Approach
With SoluPath Flex™ you'll garner not justimpartial results, but have the advantage of Patheon's years of scientificexpertise to quickly and accurately determine a scalable delivery solution thatbest suits your compound's unique characteristics. To achieve that goal, you'llhave a cross-functional team of experienced scientists dedicated to yourproject's success.