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SoluPath Flex™

SoluPath Flex™– The Customizable, Fixed-Price Solution to Rapidly Improve Solubility

Low solubility is a common but complex hurdle on the path to Phase I trials and commercialization. Through SoluPath Flex™, your project will be initiated and completed by a dedicated early development team of experts. Our early development labs afford us the agility of a start-up with the deep resources and expertise of a global pharmaceutical development leader.

Accelerate Development with a Customized Solubility Enhancement Solution

Simplicity and Clarity – Build the Best Solution Knowing Exact Costs and Timelines: The simplicity begins with a menu of services, where fixed costs and timing are spelled out in black and white.

Customizable – More Choices and More Efficiency: Select from a full array of technologies and services to tailor a unique solution that’s as unique as your challenges.

Expert Advice – A Solution Built on Scientific Expertise: At the first meeting you’ll work directly with a solubility expert from Patheon to design a solution to meet your unique requirements.

Fast – Get responsive service and rapid results. In just one meeting you’ll know the approach, cost, timing and API requirements followed quickly by a quote.

Only with SoluPath Flex™  can you plan, quote and launch a solubility enhancement solution custom tailored for your molecule, timeline and budget.

 SoluPath Flex™ Technologies

Drug Substance Characterization: Evaluate and understand the physical behavior and characteristics of your API. Leverage physical data to drive product development needs.

Solid Dispersions: Super saturated formulations that improve solubility, enhancing kinetic stability in a thermodynamically unfavorable state. Often this method achieves bioavailability targets where other options fail.

Microparticles: Micronization increases the surface area of particles to enhance the surface area for dissolution. This is a quick, low-cost, low-risk method of increasing bioavailability for many low solubility APIs.

Solubility Enhancement: Deploys an armory of solvents, co-solvents, surfactants, complexing agents, and crystallization inhibitors to improve absorption and enable larger dose volumes.

Lipid-Based Formulations: Improves absorption by using lipids, solvents and/or surfactants that solubilize, disperse and transport drugs across the gutwall.

Prototypes: Evaluate stability and performance, scale-up your product. Leverage screening information to produce prototypes for stability testing and to establish manufacturing processes.

Stability: Test chemical and physical stability of your lead formulation. Ensure the chosen technique is suitable for in vivo studies.

Manufacturing: Produce the lead drug product for PK or animal tox studies at the same facility. Test your enhanced formulation versus non-enhanced formulations.

SoluPath Flex™ Approach

With SoluPath Flex™ you'll garner not just impartial results, but have the advantage of Patheon's years of scientific expertise to quickly and accurately determine a scalable delivery solution that best suits your compound's unique characteristics. To achieve that goal, you'll have a cross-functional team of experienced scientists dedicated to your project's success.

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