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Novel Controlled Release Formulation for Orally Disintegrating Tablets Using Ion Exchange Resins

7/12/2013
Oral disintegrating tablets are designed to disintegrate rapidly in the mouth upon contact with saliva and allow oral drug delivery without chewing or a need for water plus offer other benefits such as taste masking and sustained release options. This article summarizes a simple and scalable formulation technique

Formulating and Producing Tablets Containing Large, Coated Multiparticulates

3/27/2013
Compared to bead-filled capsules, tablets are associated with better patient compliance, less risk of tampering, and lower production costs. However, the challenges of tabletting coated multiparticulates limit their production. This article summarizes how to formulate and establish process parameters for producin

Managing CMOs with Complementary Capabilities

9/17/2012
This article examines how the requirements for progressing a drug through to clinical trials include analytical characterization of the molecule, production of drug substance, manufacture of drug product, analytical method development and validation, and formulation development.

Optimizing Pharmaceutical Products Using Formulation Science

9/17/2012
Approval of new drug products that treat unmet medical needs held steady or declined over the last decade. This article summarizes techniques for formulating poorly water-soluble APIs and how selecting the right outsourcing partner can accelerate development.

Quality by Design: A Contract Organization’s Perspective

9/17/2012
This article discusses how a CDMO helps in gaining process understanding and in developing robust, high-quality products and processes. This article is part of a special issue on outsourcing.

Bridging the Gap Between Early Phase Development and Commercialisation

9/17/2012
The challenge of taking a drug candidate from discovery through to market should not be underestimated, as there can be many hurdles to face along the path. This article discusses how the careful use of external contractors during development can alleviate some of these challenges.

The Changing Environment for Pharmaceutical Development Scientists

9/4/2012
AAPS has created a task force to review the changing nature of the pharmaceutical industry, especially with respect to the shift from big pharma to small and emerging companies and any potential impact on AAPS going forward. In this article,

Disposable Technologies for Fill-Finish of Clinical Trial Materials

9/17/2012
This article examines the use and advantages of disposable technologies in the fill-finish of sterile pharmaceutical products and how these technologies can reduce costs and time in producing clinical trial materials.

The Effect of Overencapsulation on Disintegration and Dissolution

9/17/2012
This article examines the disintegration and dissolution profiles of propranolol and rofecoxib tablets overencapsulated with standard hard-gelatin capsules and with capsules specifically designed for double-blind clinical trials.

Parallel Screening

9/17/2012
Improving the bioavailability of poorly soluble new chemical entities is a leading challenge in drug development. Parallel screening is a cost-effective concept for selecting a suitable drug delivery system to enhance the chance of achieving the bioavailability target in the clinic.

CDMO Industry Update: the Worst of Times... or the Best?

9/17/2012
This article discusses how the current economic condition could provide an opportunity for the CDMO industry to grow the scope and importance of its contribution to the overall pharmaceutical industry.

Formulation Strategies for Poorly Soluble Drugs

9/17/2012
With the advent of combinatorial chemistry and high throughput screening, the number of poorly soluble drug candidates has dramatically increased. The "drugability" of new chemical entities (NCEs) and life-cycle management of marketing pharmaceutical products are becoming more challenging.
RESIDUAL IMPURITIES - Developing & Validating an Efficient Method to Determine Residuals of Hormone Products by LC-MS After Cleaning of Equipment by lya.machado@patheon.com
A rapid vehicle-screeing approach for formulating a low-solubility compound into liquid-filled capsules by lya.machado@patheon.com
Novel Controlled Release Formulation for Orally Disintegrating Tablets Using Ion Exchange Resins by Jay.Anderson
Oral disintegrating tablets are designed to disintegrate rapidly in the mouth upon contact with saliva and allow oral drug delivery without chewing or a need for water plus offer other benefits such as taste masking and sustained release options. This article summarizes a simple and scalable formulation technique and methods to achieve sustained release properties. Published in Drug Development & Delivery, June 2013.
Formulating and Producing Tablets Containing Large, Coated Multiparticulates by lya.machado@patheon.com
Compared to bead-filled capsules, tablets are associated with better patient compliance, less risk of tampering, and lower production costs. However, the challenges of tabletting coated multiparticulates limit their production. This article summarizes how to formulate and establish process parameters for producing tablets that contain large, coated multiparticulates that perform as designed. Published in Tablets and Capsules, March 2013.
Quality by Design: A Contract Organization’s Perspective by
This article discusses how a CDMO helps in gaining process understanding and in developing robust, high-quality products and processes. This article is part of a special issue on outsourcing.
The Changing Environment for Pharmaceutical Development Scientists by host
AAPS has created a task force to review the changing nature of the pharmaceutical industry, especially with respect to the shift from big pharma to small and emerging companies and any potential impact on AAPS going forward. In this article,
The Effect of Overencapsulation on Disintegration and Dissolution by
This article examines the disintegration and dissolution profiles of propranolol and rofecoxib tablets overencapsulated with standard hard-gelatin capsules and with capsules specifically designed for double-blind clinical trials.
Optimizing Pharmaceutical Products Using Formulation Science by
Approval of new drug products that treat unmet medical needs held steady or declined over the last decade. This article summarizes techniques for formulating poorly water-soluble APIs and how selecting the right outsourcing partner can accelerate development.
Parallel Screening by
Improving the bioavailability of poorly soluble new chemical entities is a leading challenge in drug development. Parallel screening is a cost-effective concept for selecting a suitable drug delivery system to enhance the chance of achieving the bioavailability target in the clinic.
Managing CMOs with Complementary Capabilities by
This article examines how the requirements for progressing a drug through to clinical trials include analytical characterization of the molecule, production of drug substance, manufacture of drug product, analytical method development and validation, and formulation development.

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