Patheon® is a leading provider of drug substance and drug product services for the global biopharmaceutical industry. SEE AND Read More »

Want to learn more?

Patheon Overview Brochure

Powders, Granules and Coated Beads

These simple, cost-effective dose forms offer you a lot of versatility as the foundation for whatever final dose form and formulation your molecule demands. And at Patheon, you'll have access to many dose forms – all royalty free – as well as formulation experience based on thousands of projects.

Powders, granules and coated beads give you more control for improved clinical benefits. They open the door to Patheon's range of controlled-release technologies. They also offer better absorption than a tablet, but are just as cost effective. What's more, these simple dose forms create a host of lifecycle management opportunities for revenue-building line extensions.

Powders & Granules Offer Unique Advantages

  • Easy to formulate and process
  • Ideal for first in man clinical studies
  • Can be made into many different dosage formulations (capsules, tablets, sachets, powders for reconstitution, dusting powders, bulk powders, powders for inhalation, effervescent powder, etc.)
  • Each dose can contain a different amount of API
  • Can be administered easily to infants and young children who cannot swallow tablets or capsules
  • Drug will have a rapid onset of action since disintegration is not required
  • Can be applied to many body cavities such as ears, nose, tooth socket, throat, etc.
  • Offer the stability of a solid dose form
  • Granules offer enhanced flowability for difficult to manufacture drugs

Coated Beads are a Simple Solution for Complex Challenges

  • Less susceptible to dose dumping with predictable gastric emptying
  • Less effected by food compared to monolithic dosage forms
  • Minimum inter- and intra-subject variability
  • Reduced risk of local irritation to GI tract
  • Multiple releases of multiple ingredients throughout GI tract in a single dose
  • Adjust dose strength, or offer a range of dose strengths, without changing the formulation or process

Methods of Delivery

  • Matrix  Systems drug particles entrapped within the matrix

  • Reservoir Systems membrane coated, diffusion controlled

  • Modified Drug Release Profiles sustained-release, delayed-release, targeted-release, pulsatile-release

Manufacturing Technologies

  • Extrusion-spheronization
  • Drug layering
  • Spray congealing

Ask The Experts

Anil Kane, Ph.D., MBA

Anil Kane, Ph.D., MBA
Dr. Kane has more than 25 years of experience in the science and business of taking molecules throug
Read More »

Joseph A. Fix, MBA, Ph.D.

Joseph A. Fix, MBA, Ph.D.
With 30 years of experience converting discoveries into businesses, Dr. Fix holds 24 patents, includ
Read More »

Larry Gatlin, Ph.D.

Larry Gatlin, Ph.D.
Dr. Gatlin is an industry veteran with more than 36 years of scientific and leadership experience. H
Read More »

Jason Vaughn, Ph.D.

Jason Vaughn, Ph.D.
Dr. Vaughn has expertise in early and preclinical development of liquid, semi-solid and solid dosage
Read More »

Leah Appel, Ph.D.

Leah Appel, Ph.D.
Dr. Appel has over 20 years’ experience in the pharmaceutical industry developing drug delivery tech
Read More »

View All »

Knowledge Library


Please fill the below form to access requested content

First Name

Last Name

Company

Title

Email

Phone

Address Line 1

Address Line 2

City

Zip/ Postal Code

Country

Submit