Patheon's Liquid-Filled Hard Capsule (LFHC) manufacturing services meet the formulation challenges facing many of today’s complex molecules. Two-piece Liquid-Filled Hard Capsules are an ideal solution for low-solubility molecules, high-potency molecules, and those susceptible to oxidation and exhibiting low melting points. LFHCs also provide increased content uniformity for low-dose products.

Available in both hard gelatin and vegetable-based HPMC (hypromellose) capsule shells, LFHCs provide additional advantages over softgel capsules, including:

• High temperature fill (up to 70°C)
• Adaptability to multiple shell systems
• Reduced water migration from shell to fill
•  Reduced fill component to shell migration
• Development scale batch capability without special equipment
• Easier validation (fewer critical process parameters)

Colorful liquid-filled hard capsule and banding options provide you with product branding opportunities for new or existing pharmaceutical products.

Patheon offers commercial scale manufacturing of two-piece LFHC products at its Cincinnati Operations location. Capsules are available in a range of capsule sizes and fill volumes in either banded or un-banded formats.

Click here to learn more about our LFHC development capabilities.