Welcome to getting solubility right the first time.

Welcome to Phase Ahead

Considering that 90% of drug candidates have solubility challenges, making sure your program is prepared for all phases of clinical trials is the fast way forward.

Try our Solubility Solution Finder

The Patheon Solubility Solution Finder

Trial and error is not a solubility strategy

Solving solubility concerns takes a combination of scientific rigor and expertise. That begins with the Patheon Solubility Solution Finder. Simply answer a few questions such as indication, dose and delivery to reveal the technologies that are most likely to help get your molecule to approval.

Click a question to answer it.

Q1:

What therapeutic indication are you targeting?

Therapeutic Area

  • Cardiovascular/Metabolic
  • CNS
  • Immunology
  • Infectious Diseases
  • Inflammation
  • Oncology
  • Lifestyle
  • Other

Q2:

What type of molecule are you working with?

Molecule Type

  • Small
  • Large

Our solubility solutions are for small molecules only. To learn more about Patheon Biologics Click here >

Q3:

What is your preferred delivery route?

Preferred Delivery Route

  • Parenteral
  • Oral Solid Dose

Our solubility solutions don’t apply to parenteral dosage forms. To learn more about our sterile capabilities Click here >

Patheon no longer provides oral liquid dose solutions. Click here to see our dose form solutions >

Patheon no longer provides topical solutions. Click here to see our dose form solutions >

Q4:

What dose?

Unit Dose

  • ≤ 50mg
  • 50mg - 200mg
  • > 200mg
Get Results

Sorry, we cannot make a determination with missing information. Please answer all questions and then click "Get Results".

Here are your best
solubility options.

(Aside from working with us, of course.)

Thank you for using the Patheon Solubility Solution Finder. Based on your input, technologies in green are most likely to deliver sufficient bioavailability with ease of scale-up. Those in yellow may work, too. Whether we provide solubility services or not, we’d like to help you maximize your molecule’s chances.

To discover your best next move contact us at 1-866-PATHEON.

Stage 1 Results

Stage 2 Results

(Click each method to learn more)

Key:

  • Need More Data
  • Not Likely
  • Possible
  • Most Likely

Size
ReductionMicronization

more +

Size
ReductionNano
Milling

more +

Amorphous
API

more +

Amorphous
DispersionsCoated
Beads

more +

x

Lipids

more +

Amorphous
DispersionsSpray
Drying

more +

Amorphous
DispersionsHot Melt
Extrusion

more +

Complexes

more +

x

Ok. Now we know which technologies may work. Tell us a little more to find your most likely options.

Congratulations on taking the time to approach solubility the right way. We’ve narrowed the choices, but getting to a specific recommendation will take a little more detail about your molecule. Simply fill in the fields to the right, then click "continue" to answer the remaining five questions.

Aqueous Solubility

  • < .001 mg/mL
  • 0.001 - 0.1 mg/mL
  • > 0.1 mg/mL

Aqueous Solubility

The maximum concentration of a drug that will dissolve in pure water at a reference temperature.

Permeability

  • < 5 x 10-6 cm/s
  • ≥ 5 x 10-6 cm/s

Permeability

The rate at which a drug passes through biological membranes. A standard reference is the Caco-2 permeability assay.

LogP

  • < 1
  • 1 - 4
  • > 4

LogP

The partition coefficient is the ratio of drug concentration in octanol versus that in water.

Melting Point

  • < 100 ℃
  • 100 – 200 ℃
  • > 200 ℃

Melting Point

The temperature at which a drug melts.

BCS Classification

  • Class I
  • Class II
  • Class III
  • Class IV

Patheon offers many solutions for Class I molecules. To learn more >

Patheon has solutions for low permability molecules. To learn more >

Class IV molecules are complex, please contact us so we can learn more about your molecule and how to solve your challenges. 1-866-PATHEON

BCS Classification

Class I: High Permeability, High Solubility
Class II: High Permeability, Low Solubility
Class III: Low Permeability, High Solubility
Class IV: Low Permeability, Low Solubility

Get Results

Sorry, we cannot make a determination with missing information. Please answer all questions and then click "Get Results".

Nothing contained in this website constitutes, or is intended to constitute, an offer, inducement, promise, or contract of any kind. All information and results listed on this website are for example and discussion only, do not represent any kind of advice or recommendation, and may not be relied on. Patheon makes no representations or warranties of any kind with respect to this site or its content, such representations and warranties being expressly disclaimed. Patheon encourages you to contact appropriate professional(s) and consultant(s) to assess your specific needs and circumstances.