The Customizable, Fixed-Price Solution to Rapidly Improve Solubility
Low solubility is a common but complex hurdle on the path to Phase I trials and commercialization. Through SoluPath Flex™, your project will be initiated and completed by a dedicated early development team of experts. Our early development labs afford us the agility of a start-up with the deep resources and expertise of a global pharmaceutical development leader.
Accelerate Development with a Customized Solubility Enhancement Solution
Simplicity and Clarity – Build the best solution knowing exact costs and timelines. The simplicity begins with a menu of services, where fixed costs and timing are spelled out in black and white.
Customizable – More choices and more efficiency. Select from a full array of technologies and services to tailor a unique solution that’s as unique as your challenges.
Expert Advice – A solution built on scientific expertise. At the first meeting you’ll work directly with a solubility expert from Patheon to design a solution to meet your unique requirements.
Fast – Get responsive service and rapid results. In just one meeting you’ll know the approach, cost, timing and API requirements followed quickly by aquote.
Only with SoluPath Flex™ can you plan, quote and launch a solubility enhancement solution custom tailored for your molecule, timeline and budget.
SoluPath Flex™ Technologies
Drug Substance Characterization: Evaluate and understand the physical behavior and characteristics of your API. Leverage physical data to drive product development needs.
Solid Dispersions: Super saturated formulations that improve solubility, enhancing kinetic stability in a thermodynamically unfavorable state. Often this method achieves bioavailability targets where other options fail.
Microparticles: Micronization increases the surface area of particles to enhance the surface area for dissolution. This is a quick, low-cost, low-risk method of increasing bioavailability for many low solubility APIs.
Solubility Enhancement: Deploys an armory of solvents, co-solvents, surfactants, complexing agents, and crystallization inhibitors to improve absorption and enable larger dose volumes.
Lipid-Based Formulations: Improves absorption by using lipids, solvents and/or surfactants that solubilize, disperse and transport drugs across the gut wall.
Prototypes: Evaluate stability and performance, scale-up your product. Leverage screening information to produce prototypes for stability testing and establish manufacturing processes.
Stability: Test chemical and physical stability of your lead formulation. Ensure the chosen technique is suitable for in vivo studies.
Manufacturing: Produce the lead drug product for PK or animal tox studies at the same facility. Test your enhanced formulation versus non-enhanced formulations.
SoluPath Flex™ Approach
With SoluPath Flex™ you'll garner not just impartial results, but have the advantage of Patheon's years of scientific expertise to quickly and accurately determine a scalable delivery solution that best suits your compound's unique characteristics. To achieve that goal, you'll have a cross-functional team of experienced scientists dedicated to your project's success.