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Patheon Overview Brochure

SoluPath Flex

The Customizable, Fixed-Price Solution to Rapidly Improve Solubility

Low solubility is a common but complex hurdle on the path to Phase I trials and commercialization. Through SoluPath Flex, your project will be initiated and completed by a dedicated early development team of experts. Our early development labs afford us the agility of a start-up with the deep resources and expertise of a global pharmaceutical development leader.

Accelerate Development with a Customized Solubility Enhancement Solution

Simplicity and Clarity – Build the best solution knowing exact costs and timelines. The simplicity begins with a menu of services, where fixed costs and timing are spelled out in black and white.

Customizable – More choices and more efficiency. Select from a full array of technologies and services to tailor a unique solution that’s as unique as your challenges.

Expert Advice – A solution built on scientific expertise. At the first meeting you’ll work directly with a solubility expert from Patheon to design a solution to meet your unique requirements.

Fast – Get responsive service and rapid results. In just one meeting you’ll know the approach, cost, timing and API requirements followed quickly by aquote.

Only with SoluPath Flex  can you plan, quote and launch a solubility enhancement solution custom tailored for your molecule, timeline and budget.

SoluPath Flex™  Technologies

Drug Substance Characterization: Evaluate and understand the physical behavior and characteristics of your API. Leverage physical data to drive product development needs.

Solid Dispersions: Super saturated formulations that improve solubility, enhancing kinetic stability in a thermodynamically unfavorable state. Often this method achieves bioavailability targets where other options fail.

Microparticles: Micronization increases the surface area of particles to enhance the surface area for dissolution. This is a quick, low-cost, low-risk method of increasing bioavailability for many low solubility APIs.

Solubility Enhancement: Deploys an armory of solvents, co-solvents, surfactants, complexing agents, and crystallization inhibitors to improve absorption and enable larger dose volumes.

Lipid-Based Formulations: Improves absorption by using lipids, solvents and/or surfactants that solubilize, disperse and transport drugs across the gut wall.

Prototypes: Evaluate stability and performance, scale-up your product. Leverage screening information to produce prototypes for stability testing and establish manufacturing processes.

Stability: Test chemical and physical stability of your lead formulation. Ensure the chosen technique is suitable for in vivo studies.

Manufacturing: Produce the lead drug product for PK or animal tox studies at the same facility. Test your enhanced formulation versus non-enhanced formulations.

SoluPath Flex™ Approach

With SoluPath Flex™ you'll garner not just impartial results, but have the advantage of Patheon's years of scientific expertise to quickly and accurately determine a scalable delivery solution that best suits your compound's unique characteristics. To achieve that goal, you'll have a cross-functional team of experienced scientists dedicated to your project's success.


Ask The Experts

Anil Kane, Ph.D., MBA

Anil Kane, Ph.D., MBA
Dr. Kane has more than 25 years of experience in the science and business of taking molecules throug
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Leah Appel, Ph.D.

Leah Appel, Ph.D.
Dr. Appel has over 20 years’ experience in the pharmaceutical industry developing drug delivery tech
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