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Supporting acceleration of global CVOT execution through site expertise and operational alignment

How site strategy and therapeutic expertise support faster study start-up and more consistent enrollment

Global cardiovascular outcomes trials (CVOTs) require scale, coordination, and sustained execution across regions. Early variability in site activation and enrollment can delay momentum and introduce risk.

This case study explores how aligning site strategy with experienced investigator networks and coordinating execution across teams supported faster activation and more consistent performance in a global Phase III CVOT.

Key development outcomes at a glance:

  • Achieved first site activation ahead of plan
  • Improved enrollment consistency across regions
  • Enabled faster study momentum in early phases

What you’ll learn in this case study:

  • How site selection impacts activation timelines
  • Why therapeutic expertise matters at scale
  • How coordinated execution supports enrollment consistency 
Thermo Fisher Scientific - Accelerating Global CVOT Execution