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Accelerating tablet technology transfer using compaction simulation

Resolving tabletability challenges before scale-up

Tabletability loss during scale-up can compromise manufacturing performance and introduce risk during technology transfer.

Case study overview

In this case study, compaction simulation conducted through the OSDPredict™ platform was applied to identify the root causes of tabletability issues and define a robust processing window. This approach supported reliable scale-up and technology transfer for the customer facing this challenge.

Using the OSDPredict™ platform, scientists were able to:

  • Identify the root causes of tabletability loss during scale-up 
  • Evaluate material and process parameters impacting performance 
  • Define a robust processing window for manufacturing 
  • Enable more reliable and efficient technology transfer processes

Key outcomes of compaction simulation

  • Improved tabletability and manufacturing consistency 
  • Reduced risk during scale-up and technology transfer 
  • Defined optimal processing parameters for robust production 
  • Increased confidence in commercial manufacturing readiness 
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