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Solving solubility challenges before they become long-term issues is critical for the success of your small molecule project. One potential development and manufacturing option to address solubility challenges is implementing a hot melt extrusion (HME) strategy to manufacture amorphous solid dispersions (ASDs).
Leveraging HME solutions can result in solvent-free processing, reduced cost of goods (COGs), and continuous manufacturing. As you build out your HME strategy, there are a variety of considerations around pharmaceutical applications, formulation, and processing to ensure your strategy is flexible, robust, and comprehensive.