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Quadrant 2™: Predictive Platform for Solubility and Bioavailability Enhancement

The Quadrant 2™ platform helps drug sponsors address solubility challenges early—before they impact program development timelines downstream.

Poorly soluble compounds often demonstrate lower bioavailability, which can reduce the efficacy of a drug substance or product. Quadrant 2™ is an artificial intelligence- and machine learning–powered tool for early drug development that enables sponsors to generate in silico predictions of how different drug formulations will behave in real-world conditions.

This diagnostic approach can save time and reduce costs by minimizing trial-and-error experimentation. Quadrant 2™ quickly identifies strategies to enhance solubility, delivering data-driven insights for smarter, faster formulation decisions. Powered by proprietary algorithms, the platform provides a comprehensive, proven predictive framework.

What you’ll learn about Quadrant 2:

This fact sheet provides a general overview of Quadrant 2, including:

  • The technology options it evaluates, from spray drying to hot melt extrusion and more
  • What the setup process looks like for a new sponsor partnering with Thermo Fisher
  • Data on the proven accuracy of the Quadrant 2™ predictive platform technology

Download this fact sheet to learn more about the Quadrant 2™ predictive platform.

Quadrant2 Predictive Platform for Solubility and Bioavailability Enhancement

Helpful resources

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