Spanning over 525,000 square feet in size, with over 105,000 square feet dedicated to cGMP production, our St. Louis, MO biologics development and manufacturing facility is a Center of Excellence for bioprocessing and single-use technology (S.U.T.), featuring the Bioprocessing Collaboration Center (BCC) and the Thermo Scientific™ HyPerforma™ DynaDrive™ Single-Use Bioreactors (S.U.B.s).
Here our experts have access to high capital equipment and resources, enabling them to create customized or optimized process development and scale-up techniques for development of bispecific, Fc-fusion, IgG1, IgG4, and various other complex protein-based biologics.
Significant investment in multiple high throughput systems provides accelerated and robust development and manufacturing. The site uses Beacon™ system for cell line development, Ambr™ 250 systems for final clone and upstream process development, Tecan™ systems for sample preparation and resin screening for downstream development, the Prometheus system for liquid formulation screening and development, in-line conditioning/dilution (ILC/ILD) skid for buffer preparation, and multi-attribute modeling (MAM) for analytical characterization.
$82.5 million expansion (2021) to enhanced production capacity with the addition of two manufacturing suites and $15 million in updated equipment, supporting 5,000 L processing scale. The expansion more than doubled the site's overall production capacity.
58,000 square foot expansion (2023) for further increased manufacturing capacity, facilitated by state and local tax incentives.
Our proven regulatory track record, having been in compliant for all audits conducted by health authorities across the globe, including but not limited to the US FDA, EMA, PMDA, EAUA, make us a well-known and trusted partner, whether you are a small and emerging biotech company just getting started or a well-resourced biopharma company seeking extended lab space.
To learn more, download our fact sheet and visitor guide.
For a tour of this state-of-the-art facility, request a site tour.