The information you provide to the chat will be recorded to improve your experience and to contact you. Please read our privacy notice to see how we are processing and protecting your data. Click to view our Cookie Notice.
We'd love your feedback—take a quick survey to help us improve.
How can we help you today?
Mammalian cell line development
Mammalian cell line development services Experts in mammalian cell lines for biologics manufacturing
At Thermo Fisher Scientific, we understand the complexities and challenges that biotech and pharmaceutical companies face when developing biologics. From early-stage development to full-scale clinical commercialization, our comprehensive cell line development (CLD) services are designed to streamline every step of your biologics journey. With over 120 PD programs executed from 2017 to present, we are confident that our dedicated team of experts can help take your program from concept to reality and help to ensure a smooth transition from development to GMP manufacturing with an efficient time-to-market and regulatory compliance.
Technical expertise
We offer expert-driven CLD, leveraging cutting-edge technologies such as AI- and ML-based gene and vector sequence optimization, transposase technology, single cell cloning, and stable clone selection to help ensure your biologic is produced efficiently.
Regulatory and quality prowess
We are committed to providing you peace of mind with our fully cGMP-compliant cell line and comprehensive regulatory support to help ensure your biologic meets stringent quality standards while minimizing regulatory delays during later stage of manufacturing.
Accelerated time-to-market
Utilization of high-throughput equipment, including the Beacon™ and Ambr™ 250 system, our robust CLD platform enables rapid cell line generation, to help speed up your biologic’s path from discovery to commercial launch without compromising quality.
Cell line development services
- Increased optimization through AI- and ML-based gene sequence optimization and vector construction
- Transposase-based technology in CHO-K1 cell line helps to enable speed to IND
- Guidance and collaboration throughout your journey from genes to final clone
- State-of-the-art, automated high-throughput equipment including Beacon system, Ambr 250 system, and Tecan™ platforms
- Platform seed train, fed-batch production, and harvest process
- Custom cell line development: use of custom or commercial cell lines, including CHO, myeloma, hybridoma, and PER.C6™ cells
- Simple cell line licensing agreements that avoid royalties or restrictions
- Regulatory guidance and support
- cGMP cell banking services
Featured resources
Blog post
The science of cell line development for biologics: Improving stability and yield
Cell line development is critical to biologics manufacturing, influencing efficiency, scalability, and product stability. Advances in CHO-K1 cell line engineering, are driving higher yields, improved gene stability, and faster IND submission pathways.
Whitepaper
Targeting cancer with therapeutic antibodies: Solutions for every phase of mAb development
This whitepaper identifies the key challenges faced at each stage of mAb development and provides guidance for streamlining pipeline progress of therapeutic mAb candidates.
Infographic
Five Ways to Get to IND/IMPD Faster
The road to IND/IMPD isn’t always easy. Balancing speed, risk, and future needs is a challenge. So how do you get to IND/IMPD faster without sacrificing quality and future commercialization goals? Check out this infographic to see suggestions from our experts about accelerating and optimizing your early development process.
Blog post
Top tips for providing the right amount of detail in first-in-human common technical documents
In the early-development stage, little may be known about a drug’s characteristics. What’s more, drug processes and formulations frequently evolve as more information emerges following testing and trials. Learn more.
Brochure
Large molecule development and manufacturing: Comprehensive offering enabling speed and flexibility
Remove complexity and bring your large molecule to market faster, with less costs and reduced risks utilizing our integrated and customizable offerings.